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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HCV-Deleobuvir
Deleobuvir

Chemical Structure : Deleobuvir

CAS No.: 863884-77-9

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Deleobuvir (BI 207127;BI207127;BI-207127)

货号: PC-60952Not For Human Use, Lab Use Only.

Deleobuvir (BI-207127, BI207127) is a potent, selective HCV NS5B polymerase inhibitor with IC50 of 50 nM against GT-1 HCV polymerase activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Deleobuvir (BI-207127, BI207127) is a potent, selective HCV NS5B polymerase inhibitor with IC50 of 50 nM against GT-1 HCV polymerase activity.
    Deleobuvir demonstrates subgenomic antiviral activity against GT1b and GT1a with EC50 of 11 and 23 nM in cell-based replicon assays.
    Deleobuvir shows weak or no inhibition in specificity assays that include poliovirus RdRp, mammalian DdRp II, and DNA polymerase α, β, and γ.
    Deleobuvir displays good antiviral potency and tolerability in early clinical trials of short-term treatment either as a single agent or in combination with pegylated IFN-α2a/ribavirin in HCV GT1 patients.

    物理化学性质&存储条件

    分子量 653.581
    分子式 C34H33BrN6O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid

    参考文献

    1. Zeuzem S, et al. Gastroenterology. 2011 Dec;141(6):2047-55; quiz e14.

    2. Zeuzem S, et al. Antivir Ther. 2013;18(8):1015-9.

    3. Larrey D, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):4727-35.

    4. LaPlante SR, et al. J Med Chem. 2014 Mar 13;57(5):1845-54.

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