Delavirdine | NNRTI | Probechem Biochemicals

Chemical Structure : Delavirdine

CAS No.: 136817-59-9

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Delavirdine (U90152, BHAP-U90152)

货号: PC-42658Not For Human Use, Lab Use Only.

Delavirdine is a potent HIV-1 reverse transcriptase inhibitor with IC50 of 0.26 uM for recombinant HIV-1 RT.

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10 mg	￥480	In stock
25 mg	￥880	In stock
100 mg	￥1580	In stock
250 mg		Get quote

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生物&药学活性

Delavirdine is a potent HIV-1 reverse transcriptase inhibitor with IC50 of 0.26 uM for recombinant HIV-1 RT.
Delavirdine exhibits IC50>440 uM for DNA polymerases α and δ.
Delavirdine blocks the replication in peripheral blood lymphocytes of 25 primary HIV-1 isolates and has low cellular cytotoxicity.
Delavirdine retains significant activity against mutant RTs (K103N, Y181C).

物理化学性质&存储条件

分子量	456.5611
分子式	C22H28N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methanesulfonamide, N-[2-[[4-[3-[(1-methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-

参考文献

1. Dueweke TJ, et al. Antimicrob Agents Chemother. 1993 May;37(5):1127-31.

2. Romero DL, et al. J Med Chem. 1993 May 14;36(10):1505-8.

3. Olmsted RA, et al. J Virol. 1996 Jun;70(6):3698-705.

Delavirdine (U90152, BHAP-U90152)

生物&药学活性

物理化学性质&存储条件

参考文献

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Delavirdine (U90152, BHAP-U90152)

生物&药学活性

物理化学性质&存储条件

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