Debio 0930 (MY 63-78) | AMPK activator | Probechem Biochemicals

Chemical Structure : Debio 0930

CAS No.: 1179347-65-9

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Debio 0930 (MT 63-78)

货号: PC-38548Not For Human Use, Lab Use Only.

Debio 0930 (MY 63-78) is a specific and potent direct AMPK activator, allosterically activates AMPK activity in prostate cancer cells with EC50 of 25 uM, without altering the energy levels.

规格	价格	库存
5 mg	￥1780	In stock
10 mg	￥2780	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

Debio 0930 (MY 63-78) is a specific and potent direct AMPK activator, allosterically activates AMPK activity in prostate cancer cells with EC50 of 25 uM, without altering the energy levels.
MT 63-78 activates AMPK mainly by binding the β1 subunit in a cell-based context, LKB1 is not essential for MT 63-78-mediated activation of AMPK.
MT 63-78 inhibits PCa cell growth and soft agar colony formation, induces mitotic arrest and apoptosis.
MT 63-78 enhances the growth inhibitory effect of AR signaling inhibitors, inhibits tumor growth in xenograft models.

物理化学性质&存储条件

分子量	326.355
分子式	C21H14N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2′,6′-Dihydroxy[1,1′-biphenyl]-4-yl)-1H-indole-3-carbonitrile

参考文献

1. Giorgia Zadra, et al. EMBO Mol Med. 2014 Apr;6(4):519-38.

Debio 0930 (MT 63-78)

生物&药学活性

物理化学性质&存储条件

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Debio 0930 (MT 63-78)

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