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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Glucocorticoid receptor (GR)-Dazucorilant
Dazucorilant

Chemical Structure : Dazucorilant

CAS No.: 1496508-34-9

Dazucorilant (CORT113176)

货号: PC-38386Not For Human Use, Lab Use Only.

Dazucorilant (CORT113176) is a potent, selective glucocorticoid receptor (GR) modulator with Ki of < 1 nM, with low or null affinity for other steroid receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Dazucorilant (CORT113176) is a potent, selective glucocorticoid receptor (GR) modulator with Ki of < 1 nM, with low or null affinity for other steroid receptors.
    Dazucorilant (CORT113176) reverses hippocampal amyloid-β peptide generation, neuroinflammation, and apoptotic processes, restores the hippocampal levels of synaptic markers, re-establishes basal plasma levels of glucocorticoids, and improves cognitive function in vivo.
    Dazucorilant (CORT113176) reversed the abnormalities of motoneurons and down-regulated proinflammatory mediators, prevented neuropathology and showed anti-inflammatory and anti-glutamatergic effects in the spinal cord of Wobbler mice.
    Dazucorilant (CORT113176) also selectively reduced binge-like EtOH intake and BECs in the HDID-1 mice.

    物理化学性质&存储条件

    分子量 582.574
    分子式 C29H22F4N4O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (R)-(1-(4-fluorophenyl)-6-((4-(trifluoromethyl)phenyl)sulfonyl)-1,4,5,6,7,8-hexahydro-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl)(pyridin-2-yl)methanone

    参考文献

    1. Pineau F, et al. Neurobiol Aging. 2016 Sep;45:109-122.

    2. Meyer M, et al. Brain Res. 2020 Jan 15;1727:146551.

    3. Savarese AM, et al. Alcohol Clin Exp Res. 2020 May;44(5):1025-1036.

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