Dauricine

Chemical Structure : Dauricine

CAS No.: 524-17-4

加入收藏

货号: PC-23750Not For Human Use, Lab Use Only.

Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, has anti-inflammatory activity, Dauricine is a natural agonist of STK11 (Serine/threonine kinase 11).

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, has anti-inflammatory activity, Dauricine is a natural agonist of STK11 (Serine/threonine kinase 11).
Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer.
Dauricine induces activation of the STK11/AMPK pathway and inhibits the growth of PC-9 cells.
Dauricine synergises the inhibitory effect with gefitinib on PC9. induces up-regulation of STK11 protein expression in vitro and in vivo, while restoring the sensitivity of PC9/GR to gefitinib by down-regulating the protein expression of Nrf2 and Pgp.

物理化学性质&存储条件

分子量	624.78
分子式	C38H44N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(4-(((R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenoxy)phenol

参考文献

1. Zhao Z, et al. Eur J Pharmacol. 2024 Dec 5;984:177024.

2. Yang Z, et al. J Cell Physiol. 2010 Oct;225(1):266-75.

3. Chen C, et al. Front Cell Dev Biol. 2021 Feb 5;8:624339.

Dauricine

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Dauricine

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.