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首页-抗体药物偶连体和PROTACs-ADC Cytotoxin-Daunorubicin hydrochloride
Daunorubicin hydrochloride

Chemical Structure : Daunorubicin hydrochloride

CAS No.: 23541-50-6

Daunorubicin hydrochloride (RP 13057 Hydrochloride;Daunomycin;RP13057 Hydrochloride;RP-13057 Hydrochloride;Rubidomycin hydrochloride)

货号: PC-43366Not For Human Use, Lab Use Only.

Daunorubicin (RP13057) hydrochloride is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells.

规格 价格 库存 数量
25 mg ¥880 In stock
50 mg ¥1380 In stock
100 mg ¥2180 In stock
250 mg ¥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Daunorubicin (RP13057) hydrochloride is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells.
Daunorubicin is a chemotherapy agent used to treat multiple cancer, secifically used for acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and Kaposi's sarcoma.
Daunorubicin and it's derivatives are widely used as payloads in antibody-drug conjugates (ADCs).

物理化学性质&存储条件

分子量 563.9808
分子式 C27H30ClNO10
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

H2O: ≥ 34 mg/mL

Chemical Name/SMILES

5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride (1:1), (8S,10S)-

参考文献

1. Latif ZA, et al. Cancer. 1980 Mar 15;45(6):1326-33.

2. Hurwitz E, et al. Int J Cancer. 1979 Oct 15;24(4):461-70.

3. Aboud-Pirak E, et al. Proc Natl Acad Sci U S A. 1989 May;86(10):3778-81.

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