Daunorubicin | Topo II inhibitor, ADC cytotoxin | Probechem Biochemicals

Chemical Structure : Daunorubicin

CAS No.: 20830-81-3

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Daunorubicin (RP13057, Daunomycin, Rubidomycin)

货号: PC-43367Not For Human Use, Lab Use Only.

Daunorubicin (Daunomycin, Rubidomycin) is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells.

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10 mg	￥480	In stock
25 mg	￥780	In stock
100 mg	￥1580	In stock
250 mg		Get quote

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生物&药学活性

Daunorubicin (Daunomycin, Rubidomycin) is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells.
Daunorubicin is a chemotherapy agent used to treat multiple cancer, secifically used for acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and Kaposi's sarcoma; Daunorubicin and it's derivatives are widely used as payloads in antibody-drug conjugates (ADCs).

物理化学性质&存储条件

分子量	527.5198
分子式	C27H29NO10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-

参考文献

1. Latif ZA, et al. Cancer. 1980 Mar 15;45(6):1326-33.

2. Hurwitz E, et al. Int J Cancer. 1979 Oct 15;24(4):461-70.

3. Aboud-Pirak E, et al. Proc Natl Acad Sci U S A. 1989 May;86(10):3778-81.

Daunorubicin (RP13057, Daunomycin, Rubidomycin)

生物&药学活性

物理化学性质&存储条件

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Daunorubicin (RP13057, Daunomycin, Rubidomycin)

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物理化学性质&存储条件

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