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首页-抗体药物偶连体和PROTACs-ADC Cytotoxin-Daun02
Daun02

Chemical Structure : Daun02

CAS No.: 290304-24-4

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Daun02 (Daun 02, Daun-02)

货号: PC-43365Not For Human Use, Lab Use Only.

Daun02 is a prodrug that is converted by β-galactosidase to Daunorubicin, specifically attenuates cocaine-induced locomotor activity, also attenuates cocaine-induced β-galactosidase expression.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Daun02 is a prodrug that is converted by β-galactosidase to Daunorubicin, specifically attenuates cocaine-induced locomotor activity, also attenuates cocaine-induced β-galactosidase expression.
    Daunorubicin, the active product of Daun02 metabolism by β-galactosidase, decreases the activity of MSNs in rat brain slices and that Daun02 strongly decreases the excitability of rat MSN primary cultures expressing β-galactosidase upon D1 dopamine receptor stimulation.
    Daun02 selectively inactivate only those neurons activated by cocaine in an environment repeatedly paired with drug injections.

    物理化学性质&存储条件

    分子量 884.7895
    分子式 C41H44N2O20
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2R,6S,18R,20S)-3-nitro-4-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)benzyl (2S,3S,4S,6R)-6-(3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yloxy)-3-hydroxy-2-methyl-tetrahydro-2H

    参考文献

    1. Koya E, et al. Nat Neurosci. 2009 Aug;12(8):1069-73.

    2. Farquhar D, et al. Cancer Chemother Pharmacol. 2002 Jul;50(1):65-70.

    3. Koya E, et al. Curr Protoc Neurosci. 2016 Jul 1;76:8.36.1-8.36.17.

    4. Cruz FC, et al. J Neurosci. 2014 May 28;34(22):7437-46.

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