Dasatinib hydrochloride |CAS:854001-07-3 Probechem Biochemicals

Chemical Structure : Dasatinib hydrochloride

CAS No.: 854001-07-3

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Dasatinib hydrochloride (BMS-354825 hydrochloride;BMS354825 hydrochloride;BMS 354825 hydrochloride)

货号: PC-42427Not For Human Use, Lab Use Only.

A potent, orally bioavailable, dual Src/Abl kinase inhibitor with IC50 of 0.5, 0.4, 0.5 and <1 nM for Src, Lck, Yes and Bcr-Abl, respectively.

规格	价格	库存
200 mg	￥520	In stock
500 mg	￥784.0	In stock
1 g		Get quote

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生物&药学活性

A potent, orally bioavailable, dual Src/Abl kinase inhibitor with IC50 of 0.5, 0.4, 0.5 and <1 nM for Src, Lck, Yes and Bcr-Abl, respectively; exhibits two-log increased potency relative to imatinib and retains activity against 14 of 15 imatinib-resistant BCR-ABL mutants; prolongs survival of mice with BCR-ABL-driven disease and inhibits proliferation of BCR-ABL-positive bone marrow progenitor cells from patients with imatinib-sensitive and imatinib-resistant CML.

Blood Cancer

Approved

物理化学性质&存储条件

分子量	524.4665
分子式	C22H27Cl2N7O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 15 mg/mL
Chemical Name/SMILES	5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-, hydrochloride (1:1)

参考文献

1. Shah NP, et al. Science. 2004 Jul 16;305(5682):399-401.

2. Schittenhelm MM, et al. Cancer Res. 2006 Jan 1;66(1):473-81.

3. Johnson FM, et al. Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6924-32.

4. Lombardo LJ, et al. J Med Chem. 2004 Dec 30;47(27):6658-61.

Dasatinib hydrochloride (BMS-354825 hydrochloride;BMS354825 hydrochloride;BMS 354825 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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询单

Dasatinib hydrochloride (BMS-354825 hydrochloride;BMS354825 hydrochloride;BMS 354825 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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