Dasabuvir | HCV NS5B inhibitor | Probechem Biochemicals

Chemical Structure : Dasabuvir

CAS No.: 1132935-63-7

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Dasabuvir (ABT333, ABT-333)

货号: PC-21355Not For Human Use, Lab Use Only.

Dasabuvir (ABT-333) is a potent, selective, and nonnucleoside inhibitor of HCV NS5B polymerase with IC50 of 2.2-10.7 nM for HCV genotype 1a and 1b.

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50 mg	￥1780	In stock
100 mg	￥2880	In stock
200 mg	￥4280	In stock
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生物&药学活性

Dasabuvir (ABT-333) is a potent, selective, and nonnucleoside inhibitor of HCV NS5B polymerase with IC50 of 2.2-10.7 nM for HCV genotype 1a and 1b.
Dasabuvir (ABT-333) displays >7,000-fold selective for HCV genotype 1 polymerases over human/mammalian polymerases.
Dasabuvir (ABT-333) inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons with EC50 values of 7.7 and 1.8 nM, respectively, with a 13-fold decrease in inhibitory activity in the presence of 40% human plasma, in HCV subgenomic replicon systems.
Dasabuvir (ABT-333) retains full activity against replicons known to confer resistance to other polymerase inhibitors, including the S282T variant in the nucleoside binding site and the M423T, P495A, P495S, and V499A single variants in the thumb domain.

物理化学性质&存储条件

分子量	493.58
分子式	C26H27N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-(3-(tert-Butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide

参考文献

1. Kati W, et al. Antimicrob Agents Chemother. 2015 Mar;59(3):1505-11.

Dasabuvir (ABT333, ABT-333)

生物&药学活性

物理化学性质&存储条件

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Dasabuvir (ABT333, ABT-333)

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物理化学性质&存储条件

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