Darunavir ethanolate |CAS:635728-49-3 Probechem Biochemicals

Chemical Structure : Darunavir ethanolate

CAS No.: 635728-49-3

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Darunavir ethanolate (TMC-114;UIC-94017)

货号: PC-45165Not For Human Use, Lab Use Only.

A potent, selective HIV-1 protease inhibitor that is extremely potent against laboratory HIV-1 strains and primary clinical isolates with IC50 of 3 nM, IC90 of 9 nM.

规格	价格	库存	数量
10 mg	￥880	In stock
50 mg	￥2640	In stock

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生物&药学活性

A potent, selective HIV-1 protease inhibitor that is extremely potent against laboratory HIV-1 strains and primary clinical isolates with IC50 of 3 nM, IC90 of 9 nM; blockes the infectivity and replication of HIV-1(NL4-3) variants with IC50 of 3-29 nM, also potent against multi-PI-resistant clinical HIV-1 variants isolated from patients; used to treat and prevent HIV/AIDS.

HIV Infection

Approved

物理化学性质&存储条件

分子量	593.732
分子式	C29H43N3O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester, compd. with ethanol (1:1)

参考文献

1. Surleraux DL, et al. J Med Chem. 2005 Mar 24;48(6):1813-22.

2. Koh Y, et al. Antimicrob Agents Chemother. 2003 Oct;47(10):3123-9.

3. King NM, et al. J Virol. 2004 Nov;78(21):12012-21.

Darunavir ethanolate (TMC-114;UIC-94017)

生物&药学活性

物理化学性质&存储条件

参考文献

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Darunavir ethanolate (TMC-114;UIC-94017)

生物&药学活性

物理化学性质&存储条件

参考文献

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