Darovasertib (LXS196) | PKC inhibitor | Probechem Biochemicals

Chemical Structure : Darovasertib

CAS No.: 1874276-76-2

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Darovasertib (NVP-LXS196, LXS196, IDE196)

货号: PC-38356Not For Human Use, Lab Use Only.

Darovasertib (NVP-LXS196, LXS 196, IDE 196) is a potent, selectve, oral pan- protein kinase C (PKC) inhibitor with IC50 of 3 nM and 0.6 nM for PKCα and PKCθ, respectively.

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生物&药学活性

Darovasertib (NVP-LXS196, LXS 196, IDE 196) is a potent, selectve, oral pan- protein kinase C (PKC) inhibitor with IC50 of 3 nM and 0.6 nM for PKCα and PKCθ, respectively.

Darovasertib (NVP-LXS196, LXS 196, IDE 196) demonstrates high potency toward classical PKC isoforms (IC50s=2.9-1.9 nM).

Darovasertib (NVP-LXS196, LXS 196, IDE 196) shows comparable cellular potency (IC50=170 nM) versus AEB071 in the 92.1 cellular proliferation assays.

Darovasertib (NVP-LXS196, LXS 196, IDE 196) demonstrates antitumor efficacy and tolerability in the 92.1 tumor xenograft model in mice.

物理化学性质&存储条件

分子量	472.47
分子式	C22H23F3N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

参考文献

1. Ellen Kapiteijn, et al. Cancer Res (2019) 79 (13_Supplement): CT068.

Darovasertib (NVP-LXS196, LXS196, IDE196)

生物&药学活性

物理化学性质&存储条件

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Darovasertib (NVP-LXS196, LXS196, IDE196)

生物&药学活性

物理化学性质&存储条件

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