Darinaparsin | Apoptosis inducer | Probechem Biochemicals

Chemical Structure : Darinaparsin

CAS No.: 69819-86-9

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Darinaparsin (ZIO-101, S-Dimethylarsino-glutathione)

货号: PC-22902Not For Human Use, Lab Use Only.

Darinaparsin (ZIO-101) is a novel arsenical apoptosis inducer, induces apoptosis and oxidative stress to a greater extent than As(2)O(3), within c-Jun NH(2)-terminal kinase-dependent.

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10 mg	￥4580	In stock
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生物&药学活性

Darinaparsin (ZIO-101) is a novel arsenical apoptosis inducer, induces apoptosis and oxidative stress to a greater extent than As(2)O(3), within c-Jun NH(2)-terminal kinase-dependent.
Darinaparsin is significantly more potent than As(2)O(3) at mediating apoptosis in various malignant cell lines and is highly active against APL cells derived for As(2)O(3) resistance.
Darinaparsin does not induce promyelocytic leukemia/retinoic acid receptor alpha (PML/RAR alpha) degradation or rearrange PML nuclear bodies in APL cells.
Darinaparsin efficiently kills tumor cells with increased antioxidant capacity and drug exporters.

物理化学性质&存储条件

分子量	411.30
分子式	C12H22AsN3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N5-((R)-1-((carboxymethyl)amino)-3-((dimethylarsaneyl)thio)-1-oxopropan-2-yl)-L-glutamine

参考文献

1. Matulis SM, et al. Mol Cancer Ther. 2009 May;8(5):1197-206.

2. Quintás-Cardama A, et al. Anticancer Agents Med Chem. 2008 Dec;8(8):904-9.

3. Diaz Z, et al. Leukemia. 2008 Oct;22(10):1853-63.

Darinaparsin (ZIO-101, S-Dimethylarsino-glutathione)

生物&药学活性

物理化学性质&存储条件

参考文献

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Darinaparsin (ZIO-101, S-Dimethylarsino-glutathione)

生物&药学活性

物理化学性质&存储条件

参考文献

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