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首页-抗体和重组蛋白-Biosimilar Antibody-Daratumumab
Daratumumab

Chemical Structure : Daratumumab

CAS No.: 945721-28-8

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Daratumumab (Anti-human CD38 mAb, human IgG1-Kappa)

货号: PC-Ab1043Not For Human Use, Lab Use Only.

Daratumumab is a human monoclonal antibody that targets CD38, depletes plasma cells and is approved for the treatment of multiple myeloma. Daratumumab inhibits the growth of CD38 expressing tumor cells and induces apoptosis (cell death) directly through mediated cross linking and by immune mediated tumor cell lysis through complement dependent cytotoxicity, antibody cell mediated cytotoxicity, and antibody dependent cellular phagocytosis..

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Daratumumab is a human monoclonal antibody that targets CD38, depletes plasma cells and is approved for the treatment of multiple myeloma. Daratumumab inhibits the growth of CD38 expressing tumor cells and induces apoptosis (cell death) directly through mediated cross linking and by immune mediated tumor cell lysis through complement dependent cytotoxicity, antibody cell mediated cytotoxicity, and antibody dependent cellular phagocytosis.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Daratumumab; Darzalex; 945721-28-8; anti-CD38; CD38 Antigen; Cluster Of Differentiation 38

参考文献

1. 1, Larysa Sanchez et al. J Hematol Oncol. 2016; 9: 51. 2, Palumbo A, et al. N Engl J Med. 2016 Aug 25;375(8):754-66. 3, Dimopoulos MA, et al. N Engl J Med. 2016 Oct 6;375(14):1319-1331. 4, de Weers M, et al. J Immunol. 2011 Feb 1;186(3):1840-8. 5, Nijhof IS, et al. Haematologica. 2015 Feb;100(2):263-8.

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