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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-Dapivirine
Dapivirine

Chemical Structure : Dapivirine

CAS No.: 244767-67-7

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Dapivirine (TMC120, R147681)

货号: PC-23582Not For Human Use, Lab Use Only.

Dapivirine (TMC120, R147681) is a potent, HIV-1 nonnucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 24 nM, inhibits syncytium formation of HIV-1 IIIB-infected CEM T cells with EC50 of 1 nM, shows high activity against wild-type and mutant HIV.

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25 mg ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Dapivirine (TMC120, R147681) is a potent, HIV-1 nonnucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 24 nM, inhibits syncytium formation of HIV-1 IIIB-infected CEM T cells with EC50 of 1 nM, shows high activity against wild-type and mutant HIV.

物理化学性质&存储条件

分子量 329.41
分子式 C20H19N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((4-(Mesitylamino)pyrimidin-2-yl)amino)benzonitrile

参考文献

1. Van Herrewege Y, et al. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9.

2. Njai HF, et al. Antivir Ther. 2005;10(2):255-62.

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