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首页-小分子抑制剂&激动剂-Others-Other Targets-Dantrolene
Dantrolene

Chemical Structure : Dantrolene

CAS No.: 7261-97-4

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Dantrolene (F368, F 368)

货号: PC-20389Not For Human Use, Lab Use Only.

Dantrolene (F368) is a muscle relaxant, non-competitively inhibitor of human erythrocyte glutathione reductase with Ki and IC50 values are 111.6 μM and 52.3 μM, respectively.

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100 mg ￥1880 In stock
250 mg ￥2980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Dantrolene (F368) is a muscle relaxant, non-competitively inhibitor of human erythrocyte glutathione reductase with Ki and IC50 values are 111.6 μM and 52.3 μM, respectively.
Dantrolene is a ryanodine receptor (RyR) antagonist and Ca2+ signaling stabilizer.
Dantrolene interferes with calcium release from the sarcoplasmic reticulum and thus to inhibit excitation-contraction coupling.
Dantrolene depresses excitation-contraction coupling in muscle fibers by inhibiting calcium release from the sarcoplasmic reticulum.
Dantrolene affects the membrane calcium channel of smooth muscle cells and inhibits calcium influx.
Dantrolene binds to domain 601-620 of RyR2 and corrects defective inter-domain interaction within RyR2 in failing hearts.

物理化学性质&存储条件

分子量 314.26
分子式 C14H10N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-

参考文献

1. W J Meyler, et al. Eur J Pharmacol. 1979 Feb 1;53(4):335-42.

2. F Zhao, et al. J Biol Chem. 2001 Apr 27;276(17):13810-6.

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