Danoprevir | HCV NS3/4A inhibitor | Probechem Biochemicals

Chemical Structure : Danoprevir

CAS No.: 850876-88-9

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Danoprevir (ITMN-191, R-7227, RO-5190591, RG7227)

货号: PC-42478Not For Human Use, Lab Use Only.

Danoprevir (ITMN-191, R-7227) is a potent, highly selective, orally available, peptidomimetic HCV NS3/4A protease inhibitor with IC50 of 0.2-0.4 nM (GT1a, 1b, 4, 5 and 6), 1.6 nM (GT2b).

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

Danoprevir (ITMN-191, R-7227) is a potent, highly selective, orally available, peptidomimetic HCV NS3/4A protease inhibitor with IC50 of 0.2-0.4 nM (GT1a, 1b, 4, 5 and 6), 1.6 nM (GT2b).
Danoprevir shows favorable potency profile against multiple HCV genotypes 1–6 and key mutants (replicon GT1b, EC50=1.6 nM).

物理化学性质&存储条件

分子量	731.8312
分子式	C35H46FN5O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a]

参考文献

1. Bae A, et al. Antimicrob Agents Chemother. 2010 Dec;54(12):5288-97.

2. Moucari R, et al. Gut. 2010 Dec;59(12):1694-8.

3. Jiang Y, et al. J Med Chem. 2014 Mar 13;57(5):1753-69.

4. Schaefer CJ, et al. Antimicrob Agents Chemother. 2011 Jul;55(7):3125-32.

Danoprevir (ITMN-191, R-7227, RO-5190591, RG7227)

生物&药学活性

物理化学性质&存储条件

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Danoprevir (ITMN-191, R-7227, RO-5190591, RG7227)

生物&药学活性

物理化学性质&存储条件

参考文献

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