Damnacanthal |Cas:477-84-9 Buy Damnacanthal from ProbeChem, Global Biochemicals Supplier

Chemical Structure : Damnacanthal

CAS No.: 477-84-9

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Damnacanthal (p56lck inhibitor)

货号: PC-70102Not For Human Use, Lab Use Only.

Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase with IC50 of 17 nM for inhibition of p56lck autophosphorylation.

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1 mg	￥3480	In stock
2 mg	￥5480	In stock
5 mg	￥8980	In stock
10 mg		Get quote
25 mg		Get quote

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生物&药学活性

Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase with IC50 of 17 nM for inhibition of p56lck autophosphorylation.
Damnacanthal also shows an IC50 of 620 nM for phosphorylation of an exogenous peptide by p56lck.
Damnacanthal displays >100-fold selectivity over PKA and PKC, modest (7-20-fold) over p60src and p59fyn.
Damnacanthal inhibits PMACI-induced IL-1β, IL-6 and TNF-α expressions by suppressing NF-κB activation and suppresses the activation of caspase-1 and the expression of RIP-2 in mast cells.
Damnacanthal also is an effective inhibitor of LIMK1/2 (IC50=0.8/1.53 uM, respectively).

物理化学性质&存储条件

分子量	282.25
分子式	C16H10O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-hydroxy-1-methoxy-9,10-dioxo-9,10-dihydroanthracene-2-carbaldehyde

参考文献

1. Faltynek CR, et al. Biochemistry. 1995 Sep 26;34(38):12404-10.

2. Kim MH, et al. Immunopharmacol Immunotoxicol. 2014 Oct;36(5):355-63.

3. Ohashi K, et al. Mol Biol Cell. 2014 Mar;25(6):828-40.

Damnacanthal (p56lck inhibitor)

生物&药学活性

物理化学性质&存储条件

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Damnacanthal (p56lck inhibitor)

生物&药学活性

物理化学性质&存储条件

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