Dalpiciclib (SHR6390) | CDK4/6 inhibitor | Probechem Biochemicals

Chemical Structure : Dalpiciclib

CAS No.: 1637781-04-4

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Dalpiciclib (SHR6390, SHR-6390)

货号: PC-38355Not For Human Use, Lab Use Only.

Dalpiciclib (SHR6390) is an orally bioavailable, small molecule CDK4/6 inhibitor, strongly inhibits tumor proliferation of ESCC in vitro and in vivo.

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5 mg	￥2780	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
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100 mg		Get quote

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生物&药学活性

Dalpiciclib (SHR6390) is an orally bioavailable, small molecule CDK4/6 inhibitor, strongly inhibits tumor proliferation of ESCC in vitro and in vivo.
SHR6390 inhibits the proliferation of retinoblastoma‐positive tumor cell lines, inhibits the CDK4/6‐RB pathway and induces G1‐phase cell cycle arrest and cellular senescence.
HR6390 combined with PTX or CDDP offered synergistic inhibitory effects in ESCC xenografts.

物理化学性质&存储条件

分子量	446.555
分子式	C25H30N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperidin-4-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one

参考文献

1. Long F, et al. Cancer Sci. 2019 Apr;110(4):1420-1430.

2. Wang J, et al. J Transl Med. 2017 Jun 2;15(1):127.

3. Chen Z, et al. Clin Transl Med. 2020 Aug;10(4):e148.

Dalpiciclib (SHR6390, SHR-6390)

生物&药学活性

物理化学性质&存储条件

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Dalpiciclib (SHR6390, SHR-6390)

生物&药学活性

物理化学性质&存储条件

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