Dalcetrapib (JTT-705, RO4607381)

Chemical Structure : Dalcetrapib

CAS No.: 211513-37-0

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货号: PC-21183Not For Human Use, Lab Use Only.

Dalcetrapib (JTT-705, RO4607381) is an orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 204.6 nM and 6 μM against recombinant human (rh) CETP and human plasma CETP, respectively.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

Dalcetrapib (JTT-705, RO4607381) is an orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 204.6 nM and 6 μM against recombinant human (rh) CETP and human plasma CETP, respectively.
Dalcetrapib (JTT-705, RO4607381) dose-dependently increases pre-β-HDL formation.
Dalcetrapib (JTT-705, RO4607381) inhibits the CETP activity of media in HepG2 in a dose-dependent manner.
Dalcetrapib (JTT-705, RO4607381) significantly increases fecal elimination of neutral sterols, bile acids, and plasma HDL-cholesterol in vivo.

物理化学性质&存储条件

分子量	389.60
分子式	C23H35NO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	S-(2-(1-(2-Ethylbutyl)cyclohexane-1-carboxamido)phenyl) 2-methylpropanethioate

参考文献

1. Niesor EJ, et al. J Lipid Res. 2010, 51(12), 3443-3454.

2. Shinkai H, et al. J Med Chem. 2000, 43(19), 3566-3572.