DZD8586 | LYN/BTK dual inhibitor | Probechem Biochemicals

Chemical Structure : DZD8586

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DZD8586 (Birelentinib, DZD 8586)

货号: PC-21570Not For Human Use, Lab Use Only.

Birelentinib (DZD8586) is an oral, non-covalent, BBB penetrant LYN and BTK dual inhibitor, overcomes resistance mutations to the approved covalent and non-covalent BTK inhibitors.

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生物&药学活性

Birelentinib (DZD8586) is an oral, non-covalent, BBB penetrant LYN and BTK dual inhibitor, overcomes resistance mutations to the approved covalent and non-covalent BTK inhibitors.
DZD8586 exhibits good selectivity against multiple kinases was assessed at Eurofins panel with purified enzymes.
DZD8586 demonstrateS concentration dependent anti-proliferative effects, with similar GI50s among cells carrying different BTK mutations.
DZD8586 exhibitS potent cell growth inhibition and induced cell death in a variety of cell lines in a panel of DLBCL cell lines.
DZD8586 (50 mg/kg) exhibitS profound tumor growth inhibition in a dose-dependent manner, and induces tumor regression in both subcutaneous and CNS tumor models.

物理化学性质&存储条件

分子量	453.45
分子式	C23H21F2N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((2S,5S)-5-(4-amino-5-(4-(2,3-difluorophenoxy)phenyl)imidazo[5,1-f][1,2,4]triazin-7-yl)tetrahydro-2H-pyran-2-yl)methanol

参考文献

1. Yu Bai, et al. Blood (2023) 142 (Supplement 1): 2822.

DZD8586 (Birelentinib, DZD 8586)

生物&药学活性

物理化学性质&存储条件

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DZD8586 (Birelentinib, DZD 8586)

生物&药学活性

物理化学性质&存储条件

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