DZ-2384 | Tubulin inhibitor | Probechem Biochemicals

Chemical Structure : DZ-2384

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DZ-2384 (DZ2384)

货号: PC-35304Not For Human Use, Lab Use Only.

DZ-2384 (DZ2384) is a microtubule-targeting agent, exhibits potent antitumor activity in models of multiple cancer types.

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生物&药学活性

DZ-2384 (DZ2384) is a microtubule-targeting agent, exhibits potent antitumor activity in models of multiple cancer types.
DZ-2384 binds the vinca domain of tubulin, DZ-2384 has potent antitumor activity as a single agent and in combination with gemcitabine both in vitro and in vivo, enhances gemcitabine activity in mouse models of pancreatic cancer.

物理化学性质&存储条件

分子量	645.677
分子式	C34H36FN5O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-((15aR,110bS,3S,6S)-3-(tert-butyl)-19-fluoro-24-(4-(hydroxymethyl)oxazol-2-yl)-5-oxo-15a,110b-dihydro-16H-4-aza-1(10b,2)-benzofuro[2,3-b]indola-2(5,2)-oxazolacycloheptaphane-6-yl)-2-hydroxy-3-methylbutanamide

参考文献

1. Ding H, et al. Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4818-22.

2. Wieczorek M, et al. Sci Transl Med. 2016 Nov 16;8(365):365ra159.

3. Bernier C, et al. Anticancer Drugs. 2018 Jun 22. doi: 10.1097/CAD.0000000000000653.

DZ-2384 (DZ2384)

生物&药学活性

物理化学性质&存储条件

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DZ-2384 (DZ2384)

生物&药学活性

物理化学性质&存储条件

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