欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-NF-κB Pathway-NF-κB-DYT-40
DYT-40

Chemical Structure : DYT-40

CAS No.: 1569312-97-5

加入收藏

DYT-40 (DYT40)

货号: PC-27553Not For Human Use, Lab Use Only.

DYT-40 is a small molecule inhibitor of Astrocyte elevated gene-1 (AEG-1) expression and NF-κB nuclear translocation, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DYT-40 is a small molecule inhibitor of Astrocyte elevated gene-1 (AEG-1) expression and NF-κB nuclear translocation, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways.
DYT-40 inhibited the proliferation of malignant glioblastoma cells.
DYT-40 induced apoptosis in U251 and U87 cells. DYT-40 inhibited epithelial-mesenchymal transition and invasion of U251 and U87 cells.
DYT-40 suppressed AEG-1/NF-κB, PI3K/AKT and MAPK pathways, decreased the phosphorylation of AKT, and ERK kinase.
DYT-40 (5, 10 and 20 mg/kg) reduced tumor volume and induced apoptotic cell death in the rat glioma model.

物理化学性质&存储条件

分子量 455.85
分子式 C22H18ClN3O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-2-(2-(4-chlorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylate

参考文献

1. Zou M, et al. Sci Rep. 2016 Jun 2;6:27331.

2. Yong-Tao Duan, et al. Bioorg Med Chem. 2014 Jun 1;22(11):2947-54.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: