DYRK2 inhibitor C17

Chemical Structure : DYRK2 inhibitor C17

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货号: PC-38492Not For Human Use, Lab Use Only.

DYRK2 inhibitor C17 is a potent, selective DYRK2 inhibitor with IC50 of 9 nM, weakly inhibits DYRK3 (IC50=68 nM), and does not inhibit DYRK1A/1B (IC50>2000 nM).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

DYRK2 inhibitor C17 is a potent, selective DYRK2 inhibitor with IC50 of 9 nM, weakly inhibits DYRK3 (IC50=68 nM), and does not inhibit DYRK1A/1B (IC50>2000 nM).
C17 showed outstanding selectivity for the human kinome containing 467 other human kinases.
C17 showed synergistic 4E-BP1 phosphorylation suppression combined with AKT and MEK inhibitors.
C17 impeded the store-operated calcium entry process (ORAI1 channel).

物理化学性质&存储条件

分子量	384.494
分子式	C21H24N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-(2,7-dimethoxy-9-((pyrrolidin-3-ylmethyl)thio)acridin-4-yl)methanol

参考文献

1. Tiantian Wei, et al. Elife. 2022 Apr 19;11:e77696.