DYRK1A/1B inhibitor 8h

Chemical Structure : DYRK1A/1B inhibitor 8h

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货号: PC-25353Not For Human Use, Lab Use Only.

DYRK1A/1B inhibitor 8h is a potent, selective DYRK1A/DYRK1B inhibitor with IC50 of 5 nM and 3 nM respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

DYRK1A/1B inhibitor 8h is a potent, selective DYRK1A/DYRK1B inhibitor with IC50 of 5 nM and 3 nM respectively.
DYRK1A/1B inhibitor 8h showed excellent cell proliferation inhibitory activity with IC50 of 3.4 uM against colon cancer cells (HCT116).
DYRK1A/1B inhibitor 8h showed remarkable cytotoxic efficacy against five colon cancer cells such as RKO, HCT116, DLD-1, SW480 and SW620 and exhibited divergent sensitivity (IC50 values of 1–38 µM).
DYRK1A/1B inhibitor 8h has excellent inhibitory activities in patient-derived colon cancer organoids model as well as in 3D spheroid assay model of SW480 and SW620.

物理化学性质&存储条件

分子量	319.32
分子式	C18H13N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl)benzene-1,2-diol

参考文献

1. Areum Park, et al. Bioorg Med Chem Lett. 2021 Sep 1:47:128226.