DY131 (GSK 9089) | ERRβ/γ agonist | Probechem Biochemicals

Chemical Structure : DY131

CAS No.: 95167-41-2

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DY131 (GSK9089, GSK 9089)

货号: PC-20414Not For Human Use, Lab Use Only.

DY131 (GSK 9089) is a selective agonist of the ERRβ/γ receptor with EC50 of 130 nM, does not affect the ERRα, ERα and β (IC50>30 uM).

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg	￥3980	In stock
250 mg		Get quote

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生物&药学活性

DY131 (GSK 9089) is a selective agonist of the ERRβ/γ receptor with EC50 of 130 nM, does not affect the ERRα, ERα and β (IC50>30 uM).
DY131 inhibits growth in a diverse panel of breast cancer cell lines, causing cell death that involves the p38 stress kinase pathway and a bimodal cell cycle arrest.
DY131 potentiate the ERRgamma-induced growth inhibition in LNCaP-ERRgamma and DU145-ERRgamma cells in a dose-dependent manner.

物理化学性质&存储条件

分子量	311.39
分子式	C18H21N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-hydroxy-benzoic acid 2-[[4-(diethylamino)phenyl]methylene]hydrazide

参考文献

1. Zuercher WJ, et al. J Med Chem. 2005 May 5;48(9):3107-9.

2. Heckler MM, et al. Oncotarget. 2016 Jul 26;7(30):47201-47220.

3. Yu DD, et al. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1311-3.

4. Yu S, et al. Cancer Res. 2007 May 15;67(10):4904-14.

DY131 (GSK9089, GSK 9089)

生物&药学活性

物理化学性质&存储条件

参考文献

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DY131 (GSK9089, GSK 9089)

生物&药学活性

物理化学性质&存储条件

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