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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-DX600
DX600

Chemical Structure : DX600

CAS No.: 478188-26-0

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DX600 (DX600, DX-600)

货号: PC-38238Not For Human Use, Lab Use Only.

DX600 (DX-600) is a potent, specific peptide inhibitor of Angiotensin-converting enzyme 2 (ACE2) with Ki of 2.8 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DX600 (DX-600) is a potent, specific peptide inhibitor of Angiotensin-converting enzyme 2 (ACE2) with Ki of 2.8 nM.
DX600 exhibits non-competitive type of inhibition and not inhibit ACE activity.
DX600 is a useful tool compound in elucidation of ACE2 in vivo function, as well as the recent SARS CoV-2 viral entry via huamn ACE2.

物理化学性质&存储条件

分子量 3188.37
分子式 C141H185N35O40S2.C2HF3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in H2O (31.8 mg/mL)
Chemical Name/SMILES

Ac-Gly-Asp-Tyr-Ser-His-Cys-Ser-Pro-Leu-Arg-Tyr-Tyr-Pro-Trp-Trp-Lys-Cys-Thr-Tyr-Pro-Asp-Pro-Glu-Gly-Gly-Gly-NH2 trifluoroacetate salt (Disulfide bond)

参考文献

1. Huang L, et al. J Biol Chem. 2003 May 2;278(18):15532-40.

2. Li N, et al. Am J Physiol Renal Physiol. 2005 Feb;288(2):F353-62.

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