DX308 | CYP26 inhibitor | Probechem Biochemicals

Chemical Structure : DX308

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DX308 (DX 308)

货号: PC-72686Not For Human Use, Lab Use Only.

DX308 is a potent, selective dual CYP26A1/B1 inhibitor and retinoic acid metabolism blocking agent.

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生物&药学活性

DX308 is a potent, selective dual CYP26A1/B1 inhibitor and retinoic acid metabolism blocking agent.
DX308 does not interact with off‐target nuclear receptors or CYP450s, is not genotoxic, and is stable in skin, despite vigorous hepatic metabolism.
Topical DX308 induces comedolysis and epidermal thickening without apparent adverse effects in vivo.
DX308 shows potent modulation of retinoid‐responsive genes by DX308 in both healthy and keratinization disorder keratinocytes (KCs).
DX308 may present an improved therapeutic alternative for the treatment of keratinization disorders and other retinoid‐responsive skin ailments.

物理化学性质&存储条件

分子量	405.538
分子式	C26H31NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-{[3-(adamantan-1-yl)-4-methoxyphenyl]amino}phenyl)propanoic Acid

参考文献

1. Joachim G S Veit, et al. J Invest Dermatol. 2021 Jan;141(1):72-83.e6.

DX308 (DX 308)

生物&药学活性

物理化学性质&存储条件

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DX308 (DX 308)

生物&药学活性

物理化学性质&存储条件

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