DX3-213B | OXPHOS complex I inhibitor | Probechem Biochemicals

Chemical Structure : DX3-213B

CAS No.: 2749555-66-4

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DX3-213B (OXPHOS inhibitor)

货号: PC-38736Not For Human Use, Lab Use Only.

DX3-213B is a potent oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 3.6 nM, inhibits pancreatic cancer cells growth in the low nanomolar range (MIA PaCa-2, GI50=11 nM).

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

DX3-213B is a potent oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 3.6 nM, inhibits pancreatic cancer cells growth in the low nanomolar range (MIA PaCa-2, GI50=11 nM).
DX3-213B disrupts adenosine triphosphate (ATP) generation (ATP depletion IC50=11 nM), inhibits complex I function.
Oral administration of DX3-213B (10 mg/kg) resulted in significant in vivo efficacy in a pancreatic cancer syngeneic model without obvious toxicity.

物理化学性质&存储条件

分子量	478.570
分子式	C20H28F2N2O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-(4,4-difluoropiperidin-1-yl)(1-((4-(isopropylsulfonyl)phenyl)sulfonyl)piperidin-3-yl)methanone

参考文献

1. Ding Xue, et al. J Med Chem. 2022 Feb 24;65(4):3404-3419.

DX3-213B (OXPHOS inhibitor)

生物&药学活性

物理化学性质&存储条件

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DX3-213B (OXPHOS inhibitor)

生物&药学活性

物理化学性质&存储条件

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