DX-8951 derivative DXd | ADC payload, Topo I inhibitor

Chemical Structure : DX-8951 derivative DXd

CAS No.: 1599440-33-1

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DX-8951 derivative DXd (DXd, Exatecan derivative for ADC)

货号: PC-28472Not For Human Use, Lab Use Only.

DX-8951 derivative DXd (DXd, Exatecan derivative for ADC) is a potent exatecan-derived topoisomerase I (Topo I) inhibitor (IC50=0.31 uM) and ADC payload.

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25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg	￥2580	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

DX-8951 derivative DXd (DXd, Exatecan derivative for ADC) is a potent exatecan-derived topoisomerase I (Topo I) inhibitor (IC50=0.31 uM) and ADC payload.

物理化学性质&存储条件

分子量	493.49
分子式	C26H24FN3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)-2-hydroxyacetamide

参考文献

1. Ogitani Y, et al. Clin Cancer Res. 2016 Oct 15;22(20):5097-5108.

DX-8951 derivative DXd (DXd, Exatecan derivative for ADC)

生物&药学活性

物理化学性质&存储条件

参考文献

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DX-8951 derivative DXd (DXd, Exatecan derivative for ADC)

生物&药学活性

物理化学性质&存储条件

参考文献

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