DWP05195 | TRPV1 antagonist | Probechem Biochemicals

Chemical Structure : DWP05195

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DWP05195 (DWP-05195)

货号: PC-26099Not For Human Use, Lab Use Only.

DWP05195 (DWP-05195) is a transient receptor potential vanilloid 1 (TRPV1) antagonist.

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生物&药学活性

DWP05195 (DWP-05195) is a transient receptor potential vanilloid 1 (TRPV1) antagonist.
DWP05195 competitively inhibit transduction of the pain signal evoked by typical TRPV1 agonists such as capsaicin, endovanilloid, anandamide, and N-arachidonoyl dopamine.
DWP05195 demonstrates a growth inhibitory effect on the five human ovarian cancer cell lines (A2780 (IC50=17.5 uM), SKOV3, OVCAR3, TOV-21G, and Hey8A).
DWP05195 induces apoptosis via both intrinsic and extrinsic apoptotic pathways in human ovarian cancer cells, induces C/EBP homologous protein (CHOP) expression and endoplasmic reticulum (ER) stress.
DWP05195 induces ER stress-induced apoptosis via the ROS-p38-CHOP pathway in human ovarian cancer cells.

物理化学性质&存储条件

分子量	419.21
分子式	C18H10BrF3N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-bromo-2-(3-(trifluoromethyl)-[2,3'-bipyridin]-6'-yl)-1H-benzo[d]imidazole

参考文献

1. Lee J, et al. Drug Des Devel Ther. 2017 Apr 24;11:1301-1313.

2. Wang YY, et al. Cancers (Basel). 2020 Jun 26;12(6):1702.

DWP05195 (DWP-05195)

生物&药学活性

物理化学性质&存储条件

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DWP05195 (DWP-05195)

生物&药学活性

物理化学性质&存储条件

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