DUX4 inhibitor C06

Chemical Structure : DUX4 inhibitor C06

加入收藏

货号: PC-27090Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

DUX4 inhibitor C06 is a potent, specific repressor of DUX4 and DUX4 target gene expression, exhibits binding to BAZ1A in vitro, also inhibits multiple kinases, including p38α, an upstream activator of DUX4.
C06 exhibited a clear dose dependent repression of DUX4-fl and its downstream targets, with IC50s of 23.78 nM for DUX4, 22.18 nM for
MBD3L2, and 21.89 nM for TRIM43.
C06 inhibits p38α signaling in differentiated FSHD myocytes with an IC50 ~4.3X higher than losmapimod.
C06 returns the DUX4 gene expression signature to a healthier profile without major effects on the muscle transcriptome in FSHD myocytes.

物理化学性质&存储条件

分子量	445.53
分子式	C24H27N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(3-((pyridin-3-yloxy)methyl)-1H-pyrazol-5-yl)urea

参考文献

1. Chang N, et al. Sci Rep. 2026 Jun 16. doi: 10.1038/s41598-026-57734-5.