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首页-小分子抑制剂&激动剂-GPCR-Adenosine Receptor-DU172
DU172

Chemical Structure : DU172

CAS No.: 321907-03-3

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DU172 (DU-172)

货号: PC-25473Not For Human Use, Lab Use Only.

DU172 (Compound 23b) is a potent, selective, covalent, irreversible antagonist of A1 adenosine receptor (A1AR), inhibits [3H]DPCPX binding to A1AR with IC50 of 21 nM, 132-fold more selective for the A1AR over the A2AAR.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DU172 (Compound 23b) is a potent, selective, covalent, irreversible antagonist of A1 adenosine receptor (A1AR), inhibits [3H]DPCPX binding to A1AR with IC50 of 21 nM, 132-fold more selective for the A1AR over the A2AAR.

物理化学性质&存储条件

分子量 519.59
分子式 C24H30FN5O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((3-(8-cyclohexyl-2,6-dioxo-1-propyl-1,2,6,7-tetrahydro-3H-purin-3-yl)propyl)carbamoyl)benzenesulfonyl fluoride

参考文献

1. Glukhova A, et al. Cell. 2017 Feb 23;168(5):867-877.e13.

2. Beauglehole AR, et al. J Med Chem. 2000 Dec 28;43(26):4973-80.

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