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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-DTHIB
DTHIB

Chemical Structure : DTHIB

CAS No.: 897326-30-6

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DTHIB (Direct Targeted HSF1 InhiBitor, SISU-102)

货号: PC-72068Not For Human Use, Lab Use Only.

DTHIB (Direct Targeted HSF1 InhiBitor, SISU-102) is a specific small molecule HSF1 inhibitor with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD).

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50 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DTHIB (Direct Targeted HSF1 InhiBitor, SISU-102) is a specific small molecule HSF1 inhibitor with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD).
HSF1 is highly expressed in human prostate cancer and is inhibited by DTHIB, suppresses AR activity and signaling.
DTHIB inhibits human prostate cancer cell proliferation (PC-3, EC50=3 uM).
DTHIB inhibits tumor growth in animal models oftherapy-resistant prostate cancer, with no weight loss or organ damage.

物理化学性质&存储条件

分子量 309.681
分子式 C13H9ClFN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-Chloro-3-nitrophenyl)-3-(4-fluorophenyl)urea

参考文献

1. Bushu Dong, et al. Sci Transl Med. 2020 Dec 16;12(574):eabb5647.

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