DT204 | SCFSkp2 inhibitor | Probechem Biochemicals

Chemical Structure : DT204

CAS No.: 428497-71-6

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DT204 (DT-204, DT 204)

货号: PC-61253Not For Human Use, Lab Use Only.

DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis.

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2 mg	￥1980	In stock
5 mg	￥3280	In stock
10 mg	￥5280	In stock
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100 mg		Get quote

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生物&药学活性

DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis.
DT204 stablizes and increases p27 levels, does not increase the level of p53, demonstrates potential synergy with CI values of 0.7, 0.8 and 0.7 for RPMI8226, U266 and MM1.S respectively combined with 1 nM BTZ, co-treatment induces apoptosis in cells resistant to the proteasome inhibitors BTZ, carfilzomib or ixazomib.
DT204 overcomes drug resistance and reduces the in vivo growth of myeloma tumors in murine models.

物理化学性质&存储条件

分子量	482.729
分子式	C19H13BrClNO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-bromo-2-((3-(4-chlorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid

参考文献

1. Malek E, et al. Leukemia. 2017 Mar;31(3):645-653.

DT204 (DT-204, DT 204)

生物&药学活性

物理化学性质&存储条件

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DT204 (DT-204, DT 204)

生物&药学活性

物理化学性质&存储条件

参考文献

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