DT-0111 | P2X2/3 antagonist | Probechem Biochemicals

Chemical Structure : DT-0111

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DT-0111 (DT0111)

货号: PC-20742Not For Human Use, Lab Use Only.

DT-0111 (DT0111) is a selective and effective, water-soluble antagonist at P2X2/3R, does not activate or block P2YR, inhibits ATP-induced current in nodose ganglionic cells with IC50 of 0.3 uM.

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生物&药学活性

DT-0111 (DT0111) is a selective and effective, water-soluble antagonist at P2X2/3R, does not activate or block P2YR, inhibits ATP-induced current in nodose ganglionic cells with IC50 of 0.3 uM.
DT-0111 markedly inhibited the activation by ATP of nodose pulmonary vagal afferents in vitro.
DT-0111 inhibited aerosolized ATP-induced bronchoconstriction and cough in vivo.

物理化学性质&存储条件

分子量	670.36
分子式	C19H25N6O15P3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Amir Pelleg, et al. Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619877960.

2. Patent US 11440935.

DT-0111 (DT0111)

生物&药学活性

物理化学性质&存储条件

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DT-0111 (DT0111)

生物&药学活性

物理化学性质&存储条件

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