DSRM-3716 | SARM1 inhibitor | Probechem Biochemicals

Chemical Structure : DSRM-3716

CAS No.: 58142-99-7

加入收藏

DSRM-3716 (DSRM3716, 5-iodoisoquinoline)

货号: PC-38164Not For Human Use, Lab Use Only.

DSRM-3716 (DSRM3716, 5-iodoisoquinoline) is a potent and selective inhibitor of NADase SARM1 with IC50 of 75 nM, displays selectivity against various NAD metabolizing and pathway enzymes (e.g., NAMPT and NMNAT).

规格	价格	库存
100 mg	￥480	In stock
250 mg	￥780	In stock
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

DSRM-3716 (DSRM3716, 5-iodoisoquinoline) is a potent and selective inhibitor of NADase SARM1 with IC50 of 75 nM.
DSRM-3716 displays selectivity against various NAD metabolizing and pathway enzymes (e.g., NAMPT and NMNAT).
DSRM-3716 recapitulates the SARM1-/- phenotype and protects axons from degeneration induced by axotomy or mitochondrial dysfunction. SARM1 inhibition post-mitochondrial injury with rotenone allows recovery and rescues axons that already entered the metastable state.
DSRM-3716 demontrates the potential to treat axonopathies of the central and peripheral nervous systems by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.

物理化学性质&存储条件

分子量	255.058
分子式	C9H6IN
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-iodoisoquinoline

参考文献

1. Robert O. Hughes, et al. Cell Rep. 2021 Jan 5; 34(1): 108588.

DSRM-3716 (DSRM3716, 5-iodoisoquinoline)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

DSRM-3716 (DSRM3716, 5-iodoisoquinoline)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.