DSR-141562 | PDE1 inhibitor | Probechem Biochemicals

Chemical Structure : DSR-141562

CAS No.: 2007975-22-4

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DSR-141562 (DSR141562)

货号: PC-47111Not For Human Use, Lab Use Only.

DSR-141562 (DSR141562) is a potent, selective orally available and brain-penetrant phosphodiesterase 1 (PDE1) inhibitor with IC50 of 97.6, 43.9 and 431.8 nM for human PDE1A, PDE1B and PDE1C, respectively.

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生物&药学活性

DSR-141562 (DSR141562) is a potent, selective orally available and brain-penetrant phosphodiesterase 1 (PDE1) inhibitor with IC50 of 97.6, 43.9 and 431.8 nM for human PDE1A, PDE1B and PDE1C, respectively.
DSR-141562 shows 2.2- and 9.8-fold selectivity for PDE1B over PDE1A and PDE1C, but has no effect or only weak inhibitory effects for other PDE families (PDE2A, IC50=2480 nM).
DSR-141562 elevated the tissue level of cGMP in mouse striatum and frontal cortex, as well as cGMP level in the monkey CSF.
DSR-141562 demonstrated efficacy in animal models for schizophrenia, DSR-141562 (3–30 mg/kg) inhibited methamphetamine-induced locomotor hyperactivity in rats.

物理化学性质&存储条件

分子量	414.429
分子式	C19H25F3N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-methyl-7-(tetrahydro-2H-pyran-4-yl)-2-{[trans-4-(trifluoromethyl)cyclohexyl]-methoxy}imidazo[5,1-f][1,2,4]triazin-4(3H)-one

参考文献

1. Enomoto T, et al. J Pharmacol Exp Ther. 2019 Dec;371(3):692-702.

DSR-141562 (DSR141562)

生物&药学活性

物理化学性质&存储条件

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DSR-141562 (DSR141562)

生物&药学活性

物理化学性质&存储条件

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