DSP-6952 hydrobromide | 5-HT4 agonist | Probechem Biochemicals

Chemical Structure : DSP-6952 hydrobromide

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DSP-6952 hydrobromide (DSP6952 hydrobromide, Minesapride hydrobromide)

货号: PC-63186Not For Human Use, Lab Use Only.

DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c.

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100 mg		Get quote

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生物&药学活性

Minesapride hydrobromide (DSP-6952) is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c.
Minesapride enhances gastric motility and causes colonic giant migrating contractions (GMCs) associated with defecation in conscious dogs, having ED50 value for inducing GMCs of 1.56 mg/kg.
Minesapride rapidly increases fecal wet weight without increasing fluid content in mice (1-10 mg/kg, p.o.).

物理化学性质&存储条件

分子量	535.864
分子式	C21H32BrClN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-amino-5-chloro-N-((4-((1-(2-hydroxyacetyl)piperidin-4-yl)methyl)morpholin-2-yl)methyl)-2-methoxybenzamide hydrobromide

参考文献

1. Mine Y, et al. Eur J Pharmacol. 2018 Feb 9;826:123-132.

2. Tsubouchi T, et al. Eur J Pharmacol. 2018 Mar 1;826:96-105.

DSP-6952 hydrobromide (DSP6952 hydrobromide, Minesapride hydrobromide)

生物&药学活性

物理化学性质&存储条件

参考文献

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DSP-6952 hydrobromide (DSP6952 hydrobromide, Minesapride hydrobromide)

生物&药学活性

物理化学性质&存储条件

参考文献

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