DSP-2342 (DSP2342)

Chemical Structure : DSP-2342

加入收藏

货号: PC-27155Not For Human Use, Lab Use Only.

DSP-2342 is potent, selective 5-hydroxytryptamine 2A/7 (5-HT2A/5-HT7) receptor antagonist with binding Ki of 1.15 nM and 2.92 nM for human 5-HT2A and 5-HT7 respectively, IC50 of 24.8 nM and 4.4 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

DSP-2342 is potent, selective 5-hydroxytryptamine 2A/7 (5-HT2A/5-HT7) receptor antagonist with binding Ki of 1.15 nM and 2.92 nM for human 5-HT2A and 5-HT7 respectively, IC50 of 24.8 nM and 4.4 nM.
DSP-2342 shows weak affinity for D2 receptors Ki values of 112 and 196 nM for the D2L and D2S receptors, respectively, also shows low affinity for receptors commonly implicated in antipsychotic-related adverse effects, including human adrenergic α1, histamine H1, and 5-HT2C re ceptors.
DSP-2342 possesses antipsychotic, anxiolytic, mood-stabilizing, and antidepressant signatures.
DSP-2342 suppressed phencyclidine- induced hyperlocomotion in mice, reduced freezing in rat contextual fear conditioning test.
DSP-2342 also attenuated aggressive behavior in resident-intruder test in Alzheimer disease model mice.
DSP-2342 restored cognitive performance in another Alzheimer disease model mice, as assessed by the novel object recognition test.
DSP-2342 increased extracellular levels of noradrenaline, dopamine, and glutamate in the medial prefrontal cortex.

物理化学性质&存储条件

分子量	363.43
分子式	C19H26FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-ethyl-N-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-3-hydroxypropanamide

参考文献

1. Hatakama H, et al. J Pharmacol Exp Ther. 2026 May 20;393(7):104949.

DSP-2342 (DSP2342)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

DSP-2342 (DSP2342)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.