DSB1559 | PARP1 inhibitor | Probechem Biochemicals

Chemical Structure : DSB1559

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DSB1559 (DSB-1559)

货号: PC-28486Not For Human Use, Lab Use Only.

DSB1559 is a potent, selective and blood-brain barrier permeable PARP1 inhibitor with IC50 of 2 nM, >2000-fold selectivity compared with PARP2.

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生物&药学活性

DSB1559 is a potent, selective and blood-brain barrier permeable PARP1 inhibitor with IC50 of 2 nM, >2000-fold selectivity compared with PARP2.
DSB1559 shows significant selectivity for PARP1 compared with other members of the PARP protein family.
has reduced hematological toxicity compared with AZD5305.
DSB1559 penetrates the blood-brain barrier and has desirable in vitro ADME and in vivo pharmacokinetic properties.
DSB1559 reduces viability and increases STING signaling of Brca1-deficient TNBC cells
DSB1559 demonstrates increased efficacy compared with olaparib in a murine model of Brca1-deficient TNBC.

物理化学性质&存储条件

分子量	427.52
分子式	C23H30FN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-(4-(3-(5-ethyl-6-oxo-1,6-dihydropyridin-2-yl)pyrrolidin-1-yl)piperidin-1-yl)-6-fluoro-N-methylpicolinamide

参考文献

1. Nelson A, et al. J Immunother Cancer. 2026 Oct 7;14(10):e014578.

DSB1559 (DSB-1559)

生物&药学活性

物理化学性质&存储条件

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DSB1559 (DSB-1559)

生物&药学活性

物理化学性质&存储条件

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