DS96432529 | Bone anabolic agent | Probechem Biochemicals

Chemical Structure : DS96432529

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DS96432529 (DS 96432529)

货号: PC-72664Not For Human Use, Lab Use Only.

DS96432529 (DS 96432529) is a potent and orally active bone anabolic agent with EC200 value of 0.024 ug/mL.

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生物&药学活性

DS96432529 (DS 96432529) is a potent and orally active bone anabolic agent with EC200 value of 0.024 ug/mL.
DS96432529 exhibited the best PK profile and high in vitro activity, showed the highest in vivo efficacy, showed significant synergistic effects when combined with alendronate or parathyroid hormone.
The mechanism of action is most likely mediated through CDK8 inhibition.

物理化学性质&存储条件

分子量	378.491
分子式	C18H26N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-amino-4-{(3S)-3-[(2-ethoxyethoxy)methyl]piperidin-1-yl}thieno[2,3-b]pyridine-2-carboxamide

参考文献

1. Keiji Saito, et al. Bioorg Med Chem Lett. 2021 Dec 15;54:128440.

DS96432529 (DS 96432529)

生物&药学活性

物理化学性质&存储条件

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DS96432529 (DS 96432529)

生物&药学活性

物理化学性质&存储条件

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