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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-DS88790512 hydrochloride
DS88790512 hydrochloride

Chemical Structure : DS88790512 hydrochloride

CAS No.:

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DS88790512 hydrochloride (DS 88790512;DS-88790512)

货号: PC-35045Not For Human Use, Lab Use Only.

DS88790512 is a potent, selective, and orally bioavailable TRPC6 blocker with IC50 of 11 nM, exhibits excellent selectivity against hERG and hNaV1.5 channels (IC50 >100 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DS88790512 is a potent, selective, and orally bioavailable TRPC6 blocker with IC50 of 11 nM, exhibits excellent selectivity against hERG and hNaV1.5 channels (IC50 >100 uM).

    物理化学性质&存储条件

    分子量 403.951
    分子式 C22H30ClN3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(((1R,3aR,7aS)-2-((R)-3-aminopiperidin-1-yl)-7a-methyl-5-oxooctahydro-1H-inden-1-yl)oxy)benzonitrile hydrochloride

    参考文献

    1. Motoyama K, et al. Bioorg Med Chem Lett. 2018 Mar 22. pii: S0960-894X(18)30251-8.

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