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首页-小分子抑制剂&激动剂-Others-Other Targets-DS69910557
DS69910557

Chemical Structure : DS69910557

CAS No.: 3032750-17-4

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DS69910557 (DS 69910557)

货号: PC-38658Not For Human Use, Lab Use Only.

DS69910557 is a highly potent, selective orally available human parathyroid hormone receptor 1 (hPTHR1) antagonist with IC50 of 0.08 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DS69910557 is a highly potent, selective orally available human parathyroid hormone receptor 1 (hPTHR1) antagonist with IC50 of 0.08 uM.
    DS69910557 demonstrated in vivo potency to decrease the plasma calcium concentration in rats upon oral administration.

    物理化学性质&存储条件

    分子量 611.539
    分子式 C32H33Cl2FN4O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1r,4r)-4-(((1-(4-(2,9-dichloro-5,5-dimethyl-6-oxo-5,6-dihydro-7H-benzo[b]pyrido[3,2-d]azepin-7-yl)phenyl)-3-fluoroazetidin-3-yl)methyl)amino)cyclohexane-1-carboxylic acid

    参考文献

    1. Yoshikazu Arai, et al. Bioorg Med Chem. 2022 Jun 15;64:116763.

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