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首页-小分子抑制剂&激动剂-Others-Other Targets-DS68591889
DS68591889

Chemical Structure : DS68591889

CAS No.: 2488609-21-6

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DS68591889 (PTDSS1i, DS 68591889)

货号: PC-21523Not For Human Use, Lab Use Only.

DS68591889 (PTDSS1i) is a potent, selective phosphatidylserine synthase 1 (PTDSS1) inhibitor, highly sellective over PTDSS2, induces phospholipid imbalance in a wide range of cancer cells.

规格 价格 库存 数量
2 mg ￥3980 In stock
5 mg ￥5580 In stock
10 mg ￥8580 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DS68591889 (PTDSS1i) is a potent, selective phosphatidylserine synthase 1 (PTDSS1) inhibitor, highly sellective over PTDSS2, induces phospholipid imbalance in a wide range of cancer cells.
DS68591889 (PTDSS1i) (1 uM) caused a substantial loss of PS and phosphatidylethanolamine, along with a slight decrease in phosphatidylglycerol (PG) and sphingomyelin (SM) and an increase in phosphatidic acid (PA) in Hela cells.
DS68591889 (PTDSS1i) (10, 30, or 100 mg/kg, oral) suppressed Jeko-1 cell engraftment in the bone marrow in B cell lymphoma in vivo.
DS68591889 (PTDSS1i) negatively regulates BCR-induced Ca2+ signaling and cell death, does not overtly affect the morphology of organelles, cell surface expression of BCR signaling components, or BCR-induced phosphorylation of downstream molecules.
DS68591889 (PTDSS1i) efficiently suppressed tumor growth and prolonged survival in mouse xenograft model.

物理化学性质&存储条件

分子量 600.50
分子式 C29H21F5N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-(5-(2,2-difluoropropyl)-4-(4-(3-methyl-4-(trifluoromethoxy)phenoxy)phenyl)-6-oxo-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzo[d]oxazol-2(3H)-one

参考文献

1. Jumpei Omi, et al. J Cell Biol. 2024 Feb 5;223(2):e202212074.

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