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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Antifolate-DS44960156
DS44960156

Chemical Structure : DS44960156

CAS No.: 2361327-08-2

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DS44960156 (DS 44960156)

货号: PC-73015Not For Human Use, Lab Use Only.

DS44960156 (DS 44960156) is a isozyme-selective MTHFD2 inhibitor with IC50 of 1.6 uM, without inhibitory effect against MTHFD1 (IC50>30 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DS44960156 (DS 44960156) is a isozyme-selective MTHFD2 inhibitor with IC50 of 1.6 uM, without inhibitory effect against MTHFD1 (IC50>30 uM).
Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a human mitochondrial enzyme that is known to play a key role in purine and thymidine syntheses by generating one-carbon (1C) units from serine.
MTHFD2 mRNA and protein are significantly increased in various types of tumors and that patients with high levels of MTHFD2 show a poor prognosis.

物理化学性质&存储条件

分子量 349.3
分子式 C20H15NO5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[(1,5-dihydro-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl)carbonyl]-benzoic acid

参考文献

1. Kawai J, et al. ACS Med Chem Lett. 2019 May 24;10(6):893-898.

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