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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-DS44470011
DS44470011

Chemical Structure : DS44470011

CAS No.: 1192586-35-8

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DS44470011 (DS 44470011)

货号: PC-22355Not For Human Use, Lab Use Only.

DS44470011 is a potent, selective hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with IC50 of 1.5 uM for HIF-PHD2, induces erythropoietin (EPO) release in Hep3B cells with EC50 of 8.4 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DS44470011 is a potent, selective hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with IC50 of 1.5 uM for HIF-PHD2, induces erythropoietin (EPO) release in Hep3B cells with EC50 of 8.4 uM.
DS44470011 is effective at inducing EPO release from cells and in vivo,with EPO10 value of 2.2 mg/kg, more potent than FG-2216.

物理化学性质&存储条件

分子量 377.40
分子式 C21H19N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2-([1,1'-biphenyl]-4-ylmethyl)-5-hydroxy-6-methylpyrimidine-4-carbonyl)glycine

参考文献

1. Fukuda T, et al. Bioorg Med Chem Lett. 2024 May 14:129799.

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