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首页-小分子抑制剂&激动剂-Others-Mitochondrial Permeability Transition Pore (mPTP)-DS44170716
DS44170716

Chemical Structure : DS44170716

CAS No.: 486993-62-8

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DS44170716 (DS-44170716, DS 44170716)

货号: PC-60363Not For Human Use, Lab Use Only.

DS44170716 is a small molecule MPT (mitochondrial permeability transition) inhibitor of that inhibits Ca2+-induced MPT in rat liver isolated mitochondria.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DS44170716 is a small molecule MPT (mitochondrial permeability transition) inhibitor of that inhibits Ca2+-induced MPT in rat liver isolated mitochondria.
    DS44170716 protects human liver HepG2 cells from Ca2+-induced death with a level of protection similar to cyclosporin A。
    DS44170716 potently inhibits mitochondrial complex III activities and weakly inhibits complex IV and V activities.

    物理化学性质&存储条件

    分子量 384.273
    分子式 C20H18BrNO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3aS,4R,9bR)-8-bromo-4-(p-tolyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-6-carboxylic acid

    参考文献

    1. Kon N, et al. Sci Rep. 2017 Jun 20;7(1):3864.

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