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首页-小分子抑制剂&激动剂-Others-Other Targets-DS42450411
DS42450411

Chemical Structure : DS42450411

CAS No.: 2247168-13-2

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DS42450411 (DS 42450411;DS-42450411)

货号: PC-35671Not For Human Use, Lab Use Only.

DS42450411 (DS 42450411, DS-42450411) is a potent, orally active hepcidin production inhibitor with IC50 of 32 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    DS42450411 (DS 42450411, DS-42450411) is a potent, orally active hepcidin production inhibitor with IC50 of 32 nM.
    The inhibition of hepcidin production of DS42450411 was suggested to be through the inhibition of DYRK1a or a kinase belonging to CMGC family.
    DS42450411 shows serum hepcidin-lowering effects in a mouse model of interleukin-6-induced acute inflammation.

    物理化学性质&存储条件

    分子量 348.494
    分子式 C22H28N4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-{1-[(1R,4R)-4-aminocyclohexyl]ethenyl}-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4-amine

    参考文献

    1. Fukuda T, et al. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3333-3337.

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