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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MNK-DS12881479
DS12881479

Chemical Structure : DS12881479

CAS No.: 2373065-59-7

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DS12881479 (DS 12881479)

货号: PC-72232Not For Human Use, Lab Use Only.

DS12881479 (DS 12881479) is a novel potent, selective inhibitor of MAPK-interacting kinase 1 (Mnk1) with IC50 of 21 nM, stabilizes the autoinhibited state of Mnk1.

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1 mg ￥1880 In stock
5 mg ￥3980 In stock
10 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DS12881479 (DS 12881479) is a novel potent, selective inhibitor of MAPK-interacting kinase 1 (Mnk1) with IC50 of 21 nM, stabilizes the autoinhibited state of Mnk1.
DS12881479 exhibits its potent inhibitory activity mainly by interacting with inactive Mnk1 (active Mnk1 IC50=416 nM).
DS12881479 has good selectivity for Mnk1 against a panel 48 active kinase, only two kinases, FLT3 and DYRK1a (>50% inhibition at 5 uM).

物理化学性质&存储条件

分子量 301.408
分子式 C16H19N3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Methyl-N-(5-phenylthiazol-2-yl)piperidine-4-carboxamide

参考文献

1. Yumi Matsui, et al. Acta Crystallogr F Struct Biol Commun. 2018 Mar 1;74(Pt 3):156-160.

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